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A total cholesterol test measures the total amount of a fatlike substance (cholesterol) in the blood. Lipoprotein analysis (lipoprotein profile or lipid profile) measures blood levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides.

The body uses cholesterol to help build cells and produce certain hormones. When there is too much cholesterol in the blood, it and other substances may begin to build up along the inside of the artery walls, forming what is known as plaque. A large deposit of plaque may obstruct the flow of blood through the artery, affecting blood flow to the heart, brain, or other vital organs. If unstable plaque tears open, it may trigger the formation of a blood clot in the artery, which can result in a heart attack or stroke.

Cholesterol travels through the blood attached to a protein. This cholesterol-protein package is called a lipoprotein. Lipoproteins are either high density or low density, depending on how much protein they have in relation to fat. Lipoproteins with more protein than fat are called high-density lipoproteins (HDL). Lipoproteins with more fat than protein are called low-density lipoproteins (LDL). Triglycerides are another type of fat that is usually measured along with cholesterol.

High-density lipoprotein cholesterol is sometimes called “good” cholesterol. HDL cholesterol helps remove LDL cholesterol from the body by binding with it in the bloodstream and carrying it back to the liver for disposal. A high level of HDL cholesterol appears to lower your risk of developing heart disease and stroke.
Low-density lipoprotein cholesterol is sometimes called “bad” cholesterol. LDL cholesterol collects inside the walls of the arteries and often contributes to the formation of plaque. LDL cholesterol is calculated from the total cholesterol, HDL, and triglyceride levels.

Total cholesterol is the sum of all cholesterol measured in a person's blood. This total includes high-density lipoprotein (HDL) cholesterol, which is sometimes called the “good cholesterol,” and low-density lipoprotein (LDL) cholesterol, sometimes called the “bad cholesterol.” Cholesterol is measured either in milligrams per deciliter of blood (mg/dL) or in millimoles per liter of blood (mmol/L).A total cholesterol level of less than 200 mg/dL (5.17 mmol/L) is desirable.200 to 239 mg/dL (5.17 to 6.18 mmol/L) is considered borderline high cholesterol.240 mg/dL (6.21 mmol/L) or higher is considered high cholesterol. The ratio of total cholesterol to “good” (HDL) cholesterol is also important, especially if total cholesterol is high.

LDL (low-density lipoprotein) cholesterol is "bad" cholesterol, which carries mostly fat and only a small amount of protein from the liver to other parts of the body. A high LDL cholesterol level is considered a risk factor for coronary artery disease (CAD) because, under certain conditions, it can cause hardening of the arteries (atherosclerosis).Cholesterol is measured either in milligrams per deciliter of blood (mg/dL) or in millimoles per liter of blood (mmol/L).An LDL cholesterol level of less than 100 mg/dL (less than 2.6 mmol/L) is considered optimal.100 to 129 (2.6 to 3.35) is considered near optimal. 130 to 158 (3.35 to 4.10) is considered borderline high.160 to 189 (4.12 to 4.88) is considered high.190 and above (4.90 to 4.88) is considered very high.People who have at least a moderate risk for developing heart disease (especially those who have diabetes) may benefit from lowering their LDL cholesterol levels. The specific target LDL level depends on a person's number and type of risk factors.

HDL (high-density lipoprotein) is sometimes called "good" cholesterol because it helps prevent cholesterol from building up in the arteries. HDL, which is made mostly of protein and only a small amount of fat, helps clear LDL (low-density lipoprotein), or “bad,” cholesterol from the body.High levels of HDL appear to help protect against heart disease. A person who is at risk for heart disease may be advised to raise his or her HDL levels by eating a balanced diet, exercising and losing weight, and stopping tobacco use. In addition, medicines may be used to raise HDL levels.

Triglycerides are a type of fat the body uses to store energy. Only a small amount of triglycerides are found in the blood. Having a high triglyceride level along with a high LDL cholesterol may increase your risk for heart disease more than having only a high LDL cholesterol level.
Some medical experts recommend routine lipoprotein analysis to screen for lipid disorders, while others may routinely choose to measure only total cholesterol and HDL levels.

Triglycerides are a type of fat that is found in the blood. They are the most common type of fat and are a major source of energy.When you eat, your body uses the calories it needs for quick energy. It converts excess calories into triglycerides and stores them in fat cells to use later. In normal amounts, triglycerides are very important to good health. However, having high triglyceride levels may increase a person's risk of developing coronary artery disease (CAD). Very high triglycerides may lead to pancreatitis in certain people.Triglyceride levels are categorized as follows: Below 150 milligrams per deciliter (mg/dL) is considered normal.150 to 199 is borderline-high.200 to 500 is high.Above 500 is very high.

All of these tests are done on a sample of blood taken from a vein.**

** Healthwise: MSN HEALTH & FITNESS; Retrieved March 10,2006 from http://health.msn.com/encyclopedia/medicaltests/articlepage.aspx?cp-documentid=100066732

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